Cardiotoxicity of Anthracyclines
نویسندگان
چکیده
منابع مشابه
Anthracyclines: cardiotoxicity and its prevention.
The anthracycline antibiotics have now been in use in curative chemotherapy protocols for over two decades. They are highly active against a wide range of haemopoietic and solid tumours in children and adults. Unfortunately, their antineoplastic use is limited by significant and irreversible cardiotoxicity, the full extent of which continues to emerge. As more children become long term survivor...
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Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and prevent anthracycline cardiotoxicity is in part due to the fact that the molecular and cellular mechanisms remain controversial and incompletely und...
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Background Anthracyclines and Herceptin are well known amongst chemotherapeutic agents to cause cardiotoxicity. Anthracyclines, particularly in combination with, Herceptin are seen in studies to cause cumulative, dose-related, progressive myocardial damage with decrease in left ventricular(LV) ejection fraction (EF) ultimately leading to clinical heart failure, which can be irreversible. There ...
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Characterization of the Changes in Cardiac Structure and Function in Mice Treated With Anthracyclines Using Serial Cardiac Magnetic Resonance Imaging Hoshang Farhad, MD; Pedro V. Staziaki, MD; Daniel Addison, MD; Otavio R. Coelho-Filho, MD, MPH; Ravi V. Shah, MD; Richard N. Mitchell, MD, PhD; Balint Szilveszter, MD; Siddique A. Abbasi, MD; Raymond Y. Kwong, MD, MPH; Marielle Scherrer-Crosbie, M...
متن کاملMitochondria Death/Survival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies
Anthracyclines remain the cornerstone of treatment in many malignancies but these agents have a cumulative dose relationship with cardiotoxicity. Development of cardiomyopathy and congestive heart failure induced by anthracyclines are typically dose-dependent, irreversible, and cumulative. Although past studies of cardiotoxicity have focused on anthracyclines, more recently interest has turned ...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2020
ISSN: 2297-055X
DOI: 10.3389/fcvm.2020.00026